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hypersensitivity to propranolol or to any of the excipients; the presence of second or third degree heart block; cardiogenic shock; a history of bronchospasm or bronchial asthma, chronic obstructive airways disease; after prolonged fasting (ie hypoglycaemia); in metabolic acidosis (eg in ); bradycardia(heart rate <45-50 beats/min); hypotension; severe peripheral arterial disturbances; sick sinus syndrome; prinzmetal’s angina; untreated phaeochromocytoma. its use may lead to hypertensive crisis.
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